Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.69 |
| ▸ | MAP3K5 | Q99683 | 8/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | STAT3 | P40763 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.58 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17297250 | 0.89 | HIF1AN (0.72) | HIF1ANMAP3K5MEN1KMT2AMCL1 | |
| SCHEMBL17296945 | 0.87 | HIF1AN (0.68) | HIF1ANMAP3K5MEN1KMT2AMCL1 | |
| SCHEMBL19593785 | 0.86 | HIF1AN (0.79) | HIF1ANMAP3K5MEN1KMT2AMCL1 | |
| SCHEMBL12698780 | 0.85 | HIF1AN (0.68) | HIF1ANMAP3K5MEN1KMT2AMCL1 | |
| SCHEMBL23433454 | 0.84 | HIF1AN (0.81) | HIF1ANMAP3K5MEN1KMT2AMCL1 | |
| SCHEMBL23433501 | 0.84 | HIF1AN (0.81) | HIF1ANMAP3K5MEN1KMT2AMCL1 | |
| SCHEMBL8290210 | 0.83 | HIF1AN (0.83) | HIF1ANMAP3K5MEN1KMT2AMCL1 | |
| SCHEMBL3905770 | 0.83 | HIF1AN (0.83) | HIF1ANMAP3K5MEN1KMT2AMCL1 | |
| SCHEMBL3905768 | 0.83 | HIF1AN (0.83) | HIF1ANMAP3K5MEN1KMT2AMCL1 | |
| Claficapavir SCHEMBL6789043 | 0.82 | HIF1AN (1.00) | HIF1ANMAP3K5MEN1KMT2AMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9199918-B2 | Small molecule inhibitors of AGBL2 | GEORGETOWN UNIVERSITY (US) | 2015-12-01 | — | — | US | disclosed |