Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 7/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1730755 | 0.95 | F2R (0.38) | F2RPTGS1PTGS2 | |
| Bromide SCHEMBL1732249 | 0.93 | F2R (0.37) | F2RPTGS1PTGS2 | |
| Bromide SCHEMBL1729506 | 0.90 | F2R (0.38) | F2RPTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL5484989 | 0.90 | F2R (0.39) | F2RPTGS1PTGS2 | |
| Bromide SCHEMBL1732674 | 0.89 | F2R (0.35) | F2RPTGS1PTGS2 | |
| Bromide SCHEMBL1730777 | 0.87 | F2R (0.36) | F2RPTGS1PTGS2 | |
| Bromide SCHEMBL1732601 | 0.87 | F2R (0.36) | F2RPTGS1PTGS2 | |
| Bromide SCHEMBL1732135 | 0.86 | F2R (0.35) | F2RPTGS1PTGS2 | |
| SCHEMBL14468948 | 0.86 | F2R (0.33) | F2RPTGS1PTGS2 | |
| SCHEMBL14449137 | 0.86 | F2R (0.33) | F2RPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391451-B1 | 2-IMINOPYRROLIDINE DERIVATES | EISAI R&D MAN CO LTD (JP) | 2011-11-23 | — | — | EP | disclosed |