Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 20/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728186 | 0.90 | HRH3 (0.62) | HRH3KCNH2CYP3A4 | |
| SCHEMBL1730278 | 0.90 | HRH3 (0.73) | HRH3KCNH2CYP3A4 | |
| SCHEMBL1727985 | 0.90 | HRH3 (0.73) | HRH3KCNH2CYP3A4 | |
| SCHEMBL1730277 | 0.89 | HRH3 (0.66) | HRH3KCNH2CYP3A4 | |
| SCHEMBL1729671 | 0.86 | HRH3 (1.00) | HRH3KCNH2CYP3A4 | |
| SCHEMBL1729463 | 0.86 | HRH3 (0.73) | HRH3KCNH2CYP3A4 | |
| Cyclopropane SCHEMBL2427283 | 0.83 | HRH3 (0.78) | HRH3KCNH2CYP3A4 | |
| SCHEMBL2428316 | 0.82 | HRH3 (0.63) | HRH3KCNH2CYP3A4 | |
| SCHEMBL2431103 | 0.82 | HRH3 (0.73) | HRH3KCNH2CYP3A4 | |
| SCHEMBL221547 | 0.82 | HRH3 (0.87) | HRH3KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215058-B1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2011-11-23 | — | — | EP | claimed |