Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 20/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729463 | 0.90 | HRH3 (0.73) | HRH3CYP3A4KCNH2 | |
| SCHEMBL1730366 | 0.90 | HRH3 (0.74) | HRH3CYP3A4KCNH2 | |
| SCHEMBL1728136 | 0.89 | HRH3 (0.74) | HRH3CYP3A4KCNH2 | |
| SCHEMBL1728145 | 0.87 | HRH3 (1.00) | HRH3CYP3A4KCNH2 | |
| SCHEMBL1730716 | 0.86 | HRH3 (0.79) | HRH3CYP3A4 | |
| SCHEMBL1728321 | 0.85 | HRH3 (0.65) | HRH3CYP3A4KCNH2 | |
| SCHEMBL1730725 | 0.83 | HRH3 (0.73) | HRH3CYP3A4KCNH2 | |
| Trifluoroacetic Acid SCHEMBL1728097 | 0.81 | HRH3 (0.87) | HRH3CYP3A4KCNH2 | |
| SCHEMBL1728127 | 0.79 | HRH3 (1.00) | HRH3CYP3A4KCNH2 | |
| Cyclopropane SCHEMBL2428838 | 0.79 | HRH3 (0.79) | HRH3CYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215058-B1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE UREAS AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2011-11-23 | — | — | EP | claimed |