Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 15/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1731022 | 0.88 | KDM4E (0.38) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1731018 | 0.88 | F2R (0.38) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL1730470 | 0.85 | KDM4E (0.44) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5490666 | 0.82 | KDM4E (0.48) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1729108 | 0.82 | KDM4E (0.50) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL1731327 | 0.80 | F2R (0.39) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL1729027 | 0.79 | KDM4E (0.40) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL1730571 | 0.79 | F2R (0.46) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1731025 | 0.78 | KDM4E (0.44) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL1730858 | 0.78 | F2R (0.43) | F2RKDM4EMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391451-B1 | 2-IMINOPYRROLIDINE DERIVATES | EISAI R&D MAN CO LTD (JP) | 2011-11-23 | — | — | EP | disclosed |
| US-7244730-B2 | 2-iminopyrrolidine derivatives | EISAI CO., LTD (JP) | 2007-07-17 | — | — | US | disclosed |
| US-20050245592-A1 | 2-Iminopyrrolidine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-11-03 | — | — | US | disclosed |
| US-20050004204-A1 | 2-Iminopyrrolidine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245592-A1 | 2-Iminopyrrolidine derivatives | H1-2, H1-3, H1-0 | F2R 2290/4885KDM4E 3161/4885MAPT 3483/4885 |
| US-20050004204-A1 | 2-Iminopyrrolidine derivatives | H1-2, H1-3, H1-0 | F2R 2289/4885KDM4E 3132/4885MAPT 3440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.