Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 20/20 | 0.86 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15921833 | 1.00 | MDM2 (0.86) | MDM2TP53 | |
| SCHEMBL15930924 | 0.93 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL15922206 | 0.88 | MDM2 (0.87) | MDM2TP53 | |
| SCHEMBL15924482 | 0.86 | MDM2 (0.88) | MDM2 | |
| SCHEMBL15924480 | 0.86 | MDM2 (0.88) | MDM2 | |
| SCHEMBL15921835 | 0.86 | MDM2 (0.65) | MDM2 | |
| SCHEMBL17314342 | 0.84 | MDM2 (0.75) | MDM2TP53 | |
| SCHEMBL17314341 | 0.84 | MDM2 (0.75) | MDM2TP53 | |
| SCHEMBL15922103 | 0.84 | MDM2 (0.89) | MDM2 | |
| SCHEMBL15922101 | 0.84 | MDM2 (0.89) | MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9540377-B2 | 2,6,7,8 substituted purines as HDM2 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-01-10 | — | — | US | disclosed |
| US-20150353553-A1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353553-A1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | DDX21, DPYD, NSUN2 | MDM2 55/4885TP53 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.