Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | DGKA | P23743 | 1/20 | 0.47 |
| ▸ | PAM | P19021 | 2/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.43 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9228629 | 0.98 | TLR4 (0.51) | TLR4SLC2A1DGKAPAMLPAR1 | |
| SCHEMBL17866084 | 0.98 | TLR4 (0.51) | TLR4SLC2A1DGKAPAMLPAR1 | |
| SCHEMBL17318241 | 0.98 | TLR4 (0.51) | TLR4SLC2A1DGKAPAMLPAR1 | |
| SCHEMBL6286986 | 0.97 | TLR4 (0.53) | TLR4SLC2A1DGKAPAMLPAR1 | |
| SCHEMBL8506716 | 0.97 | TLR4 (0.53) | TLR4SLC2A1DGKAPAMLPAR1 | |
| SCHEMBL9231092 | 0.97 | TLR4 (0.53) | TLR4SLC2A1DGKAPAMLPAR1 | |
| SCHEMBL13561243 | 0.97 | TLR4 (0.53) | TLR4SLC2A1DGKAPAMLPAR1 | |
| SCHEMBL12427213 | 0.97 | TLR4 (0.53) | TLR4SLC2A1DGKAPAMLPAR1 | |
| SCHEMBL9229342 | 0.97 | TLR4 (0.53) | TLR4SLC2A1DGKAPAMLPAR1 | |
| SCHEMBL21662370 | 0.97 | TLR4 (0.53) | TLR4SLC2A1DGKAPAMLPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3152220-A1 | NICOTINAMIDE RIBOSIDE ANALOGS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-04-12 | — | — | EP | claimed |
| WO-2015186114-A1 | NICOTINAMIDE RIBOSIDE ANALOGS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-12-10 | — | — | WO | claimed |