Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.61 |
| ▸ | EGFR | P00533 | 12/20 | 0.61 |
| ▸ | LCK | P06239 | 12/20 | 0.61 |
| ▸ | ITK | Q08881 | 10/20 | 0.61 |
| ▸ | JAK3 | P52333 | 4/20 | 0.61 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.39 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL410073 | 0.89 | BTK (0.78) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL16802288 | 0.82 | BTK (0.77) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL409213 | 0.80 | BTK (0.79) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL17703365 | 0.80 | BTK (0.66) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL410081 | 0.79 | BTK (0.82) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL409254 | 0.76 | BTK (1.00) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL29663809 | 0.76 | BTK (1.00) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL14643775 | 0.76 | BTK (0.78) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL409226 | 0.75 | BTK (0.76) | BTKEGFRLCKITKJAK3 | |
| SCHEMBL14617768 | 0.74 | BTK (0.80) | BTKEGFRLCKITKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526934-B1 | Inhibitors of bruton's tyrosine kinase | PHARMACYCLICS LLC (US) | 2015-12-09 | — | — | EP | disclosed |