Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 14/20 | 0.51 |
| ▸ | SYK | P43405 | 4/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12112087 | 1.00 | IRAK4 (0.51) | IRAK4SYKMAP3K7METALK | |
| SCHEMBL10171291 | 1.00 | IRAK4 (0.51) | IRAK4SYKMAP3K7METALK | |
| SCHEMBL10171215 | 1.00 | IRAK4 (0.51) | IRAK4SYKMAP3K7METALK | |
| SCHEMBL10171952 | 1.00 | IRAK4 (0.51) | IRAK4SYKMAP3K7METALK | |
| SCHEMBL10171964 | 0.91 | IRAK4 (0.54) | IRAK4MAP3K7KDRAURKB | |
| SCHEMBL10171242 | 0.89 | IRAK4 (0.55) | IRAK4MAP3K7ALKKDRAURKB | |
| SCHEMBL10171455 | 0.88 | IRAK4 (0.64) | IRAK4SYKMAP3K7METALK | |
| SCHEMBL10171448 | 0.88 | IRAK4 (0.54) | IRAK4MAP3K7 | |
| SCHEMBL10171260 | 0.86 | IRAK4 (0.51) | IRAK4MAP3K7 | |
| SCHEMBL10171471 | 0.85 | IRAK4 (0.53) | IRAK4MAP3K7KDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960372-B1 | KINASE INHIBITORS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2015-12-09 | — | — | EP | disclosed |