Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 10/20 | 0.52 |
| ▸ | PDE7B | Q9NP56 | 5/20 | 0.52 |
| ▸ | PDE8A | O60658 | 3/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | TOP1 | P11387 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL101167 | 0.93 | PDE7A (0.53) | PDE7APDE7BPDE8ACYP11B1NPSR1 | |
| SCHEMBL100928 | 0.91 | PDE7A (0.58) | PDE7APDE7BPDE8AOPRM1OPRL1 | |
| SCHEMBL30837867 | 0.91 | PDE7A (0.58) | PDE7APDE7BPDE8AOPRM1OPRL1 | |
| SCHEMBL101005 | 0.90 | PDE7A (0.56) | PDE7APDE7BPDE8ACYP11B1ALDH1A1 | |
| SCHEMBL100993 | 0.90 | PDE7A (0.55) | PDE7APDE7BPDE8ACYP11B1CYP11B2 | |
| SCHEMBL100103 | 0.88 | PDE7A (0.55) | PDE7APDE7BPDE8ACYP11B1CYP11B2 | |
| SCHEMBL100395 | 0.87 | PDE7A (0.62) | PDE7APDE7BPDE8AOPRM1OPRL1 | |
| SCHEMBL30837936 | 0.87 | PDE7A (0.62) | PDE7APDE7BPDE8AOPRM1OPRL1 | |
| SCHEMBL100396 | 0.86 | PDE7A (0.53) | PDE7APDE7BPDE8ACYP11B1CYP11B2 | |
| SCHEMBL32681322 | 0.86 | PDE7A (0.53) | PDE7APDE7BPDE8ACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058987-A1 | THERAPEUTIC USES OF QUINAZOLINEDIONE DERIVATIVES | SANOFI (FR) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058987-A1 | THERAPEUTIC USES OF QUINAZOLINEDIONE DERIVATIVES | SLC5A2, SLC5A1, PPARD | PDE7A 1520/4885PDE7B 1364/4885PDE8A 2069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.