Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 11/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.32 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1731268 | 0.93 | F2R (0.43) | F2RKDM4ENPC1MAPTRAB9A | |
| Bromide SCHEMBL1731334 | 0.92 | F2R (0.43) | F2RKDM4ENPC1MAPTRAB9A | |
| Bromide SCHEMBL1731361 | 0.92 | F2R (0.43) | F2RKDM4ENPC1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL1730854 | 0.90 | F2R (0.43) | F2RKDM4ENPC1MAPTRAB9A | |
| Bromide SCHEMBL1730405 | 0.89 | F2R (0.45) | F2RKMT2AMEN1KDM4ENPC1 | |
| Bromide SCHEMBL6363837 | 0.89 | F2R (0.44) | F2RKDM4ENPC1MAPTRAB9A | |
| SCHEMBL14449014 | 0.88 | F2R (0.45) | F2RKMT2AMEN1KDM4ENPC1 | |
| Bromide SCHEMBL1730602 | 0.87 | CYP3A4 (0.42) | F2RKDM4ENPC1MAPTRAB9A | |
| Bromide SCHEMBL1731960 | 0.86 | F2R (0.40) | F2RKDM4ENPC1MAPTRAB9A | |
| Bromide SCHEMBL1729002 | 0.86 | F2R (0.44) | F2RKDM4ENPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391451-B1 | 2-IMINOPYRROLIDINE DERIVATES | EISAI R&D MAN CO LTD (JP) | 2011-11-23 | — | — | EP | disclosed |