Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 16/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1730620 | 0.92 | F2R (0.51) | F2RKDM4ERAB9AMAPTNPC1 | |
| SCHEMBL12151783 | 0.91 | F2R (0.51) | F2RKDM4ERAB9AMAPTNPC1 | |
| Bromide SCHEMBL5486569 | 0.90 | F2R (0.49) | F2RKDM4ERAB9AMAPTNPC1 | |
| Bromide SCHEMBL1728919 | 0.90 | F2R (0.48) | F2RKDM4ERAB9AMAPTNPC1 | |
| Bromide SCHEMBL1728702 | 0.89 | F2R (0.54) | F2RKDM4ERAB9AMAPTNPC1 | |
| SCHEMBL14449154 | 0.89 | F2R (0.48) | F2RKDM4ERAB9AMAPTNPC1 | |
| SCHEMBL1729455 | 0.89 | F2R (0.42) | F2RKDM4ERAB9AMAPTNPC1 | |
| SCHEMBL14449120 | 0.89 | F2R (0.53) | F2RKDM4ERAB9AMAPTNPC1 | |
| Bromide SCHEMBL1732780 | 0.88 | F2R (0.48) | F2RKDM4ERAB9AMAPTNPC1 | |
| Bromide SCHEMBL1731182 | 0.88 | F2R (0.40) | F2RKDM4ERAB9AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391451-B1 | 2-IMINOPYRROLIDINE DERIVATES | EISAI R&D MAN CO LTD (JP) | 2011-11-23 | — | — | EP | disclosed |