Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 6/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.31 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1729718 | 0.92 | F2R (0.39) | F2R | |
| Bromide SCHEMBL1729257 | 0.90 | F2R (0.37) | F2RPTGS1PTGS2 | |
| Bromide SCHEMBL1732250 | 0.90 | F2R (0.36) | F2R | |
| Bromide SCHEMBL1731876 | 0.88 | F2R (0.39) | F2R | |
| Bromide SCHEMBL1729969 | 0.88 | F2R (0.36) | F2R | |
| Bromide SCHEMBL1731166 | 0.88 | F2R (0.46) | F2RCYSLTR2CYSLTR1 | |
| Bromide SCHEMBL1732614 | 0.86 | F2R (0.34) | F2R | |
| Trifluoroacetic Acid SCHEMBL1728671 | 0.85 | F2R (0.37) | F2R | |
| Bromide SCHEMBL5483964 | 0.84 | F2R (0.34) | F2R | |
| Bromide SCHEMBL5488711 | 0.84 | F2R (0.34) | F2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391451-B1 | 2-IMINOPYRROLIDINE DERIVATES | EISAI R&D MAN CO LTD (JP) | 2011-11-23 | — | — | EP | disclosed |