Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10422857 | 0.89 | KDM4E (0.35) | SMYD2ALKCYP3A4 | |
| SCHEMBL31520986 | 0.88 | SMYD2 (0.35) | SMYD2CYP3A4HTTSMN1; SMN2 | |
| SCHEMBL542769 | 0.88 | SMYD2 (0.34) | SMYD2ALKCYP3A4HTTSMN1; SMN2 | |
| SCHEMBL1733644 | 0.85 | SMYD2 (0.33) | SMYD2ALKCYP3A4HTTSMN1; SMN2 | |
| SCHEMBL31092036 | 0.83 | SMYD2 (0.37) | SMYD2ALKCYP3A4HTTSMN1; SMN2 | |
| SCHEMBL23857733 | 0.82 | CYP3A4 (0.31) | SMYD2CYP3A4HTTSMN1; SMN2 | |
| SCHEMBL17093480 | 0.81 | SMYD2 (0.34) | SMYD2ALKCYP3A4HTTSMN1; SMN2 | |
| SCHEMBL3638318 | 0.81 | SMYD2 (0.36) | SMYD2ALKCYP3A4HTTSMN1; SMN2 | |
| SCHEMBL10422864 | 0.80 | SMYD2 (0.31) | SMYD2ALK | |
| SCHEMBL13093647 | 0.79 | SMYD2 (0.35) | SMYD2CYP3A4HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222257-B2 | Phosphono-pent-2-en-1-yl nucleosides and analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-17 | — | — | US | disclosed |
| US-8222257-B2 | Phosphono-pent-2-en-1-yl nucleosides and analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-17 | — | — | US | disclosed |
| EP-1866319-B1 | PHOSPHONO-PENT-2-EN-1-YL NUCLEOSIDES AND ANALOGS | UNIV CALIFORNIA (US) | 2011-11-23 | — | — | EP | disclosed |
| US-20090215726-A1 | Phosphono-Pent-2-en-1-yl Nucleosides and Analogs | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-08-27 | — | — | US | disclosed |
| US-20090215726-A1 | Phosphono-Pent-2-en-1-yl Nucleosides and Analogs | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215726-A1 | Phosphono-Pent-2-en-1-yl Nucleosides and Analogs | PNP, TYMP, ENPP1 | SMYD2 3961/4885ALK 3198/4885CYP3A4 4124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.