SCHEMBL1733774

SCHEMBL1733774

COc1ccc([C@@H](CCCNC(=O)Oc2ccc(S(C)(=O)=O)s2)N2C(=O)c3cccc(N4CCN([C@H](C)c5ccccc5)CC4)c3C2=O)cc1OC

nearest known ligand 0.76

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 18/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1472211 0.91 UTS2R (0.73) UTS2R
SCHEMBL1733568 0.89 UTS2R (0.81) UTS2R
SCHEMBL1733548 0.87 UTS2R (0.74) UTS2R
SCHEMBL12828607 0.86 UTS2R (1.00) UTS2R
SCHEMBL1472830 0.86 UTS2R (1.00) UTS2R
SCHEMBL9884538 0.86 UTS2R (1.00) UTS2R
SCHEMBL1472607 0.86 UTS2R (1.00) UTS2R
SCHEMBL1733847 0.86 UTS2R (0.78) UTS2R
SCHEMBL9884506 0.86 UTS2R (0.84) UTS2R
SCHEMBL1734216 0.86 UTS2R (0.80) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1993554-B1 UROTENSIN II RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2011-11-23 EP claimed