Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.68 |
| ▸ | PDE4A | P27815 | 3/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.68 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.68 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17337964 | 0.79 | PDE4A (0.65) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL17337965 | 0.78 | PDE4A (0.64) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL17338005 | 0.77 | CNR2 (0.64) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL11895927 | 0.77 | PDE4A (0.86) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL17337940 | 0.76 | PDE4A (0.61) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL18858383 | 0.76 | PDE4A (0.60) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL17337959 | 0.74 | PDE4A (0.59) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL6913073 | 0.73 | PDE4A (0.64) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL2896150 | 0.73 | PDE4A (0.61) | PDE4BPDE4DPDE4APDE4CPDE3B | |
| SCHEMBL2207329 | 0.73 | PDE4A (0.57) | PDE4BPDE4DPDE4APDE4CPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170137419-A1 | DERIVATIVES OF 2H-PYRAZOLO[4,3-C]QUINOLIN-3(5H)-ONE AND USE THEREOF | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2017-05-18 | — | — | US | disclosed |
| EP-3154981-A1 | DERIVATIVES OF 2H-PYRAZOLO[4,3-C]QUINOLIN-3(5H)-ONE AND USE THEREOF | Université du Droit et de la Santé de Lille 2 (FR) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015189523-A1 | DERIVATIVES OF 2H-PYRAZOLO[4,3-C]QUINOLIN-3(5H)-ONE AND USE THEREOF | UNIVERSITE DU DROIT ET DE LA SANTE LILLE 2 (FR) | 2015-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170137419-A1 | DERIVATIVES OF 2H-PYRAZOLO[4,3-C]QUINOLIN-3(5H)-ONE AND USE THEREOF | CYP3A43, CYP3A5, CYP2D6 | PDE4B 424/4885PDE4D 445/4885PDE4A 575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.