SCHEMBL17338245

SCHEMBL17338245

CC(CCNc1ncnc(N)c1C#N)Cc1nc2cccc(Cl)c2c(=O)n1N1CCNCC1

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 20/20 0.69
PIK3R2 O00459 16/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17338213 0.89 PIK3CD (0.68) PIK3CDPIK3R2
SCHEMBL17338299 0.88 PIK3CD (0.66) PIK3CDPIK3R2
SCHEMBL17338264 0.83 PIK3CD (0.69) PIK3CDPIK3R2
SCHEMBL17330519 0.82 PIK3CD (1.00) PIK3CDPIK3R2
SCHEMBL17330523 0.82 PIK3CD (1.00) PIK3CDPIK3R2
SCHEMBL17338156 0.80 PIK3CD (0.68) PIK3CDPIK3R2
SCHEMBL17330619 0.80 PIK3CD (1.00) PIK3CDPIK3R2
SCHEMBL17330618 0.80 PIK3CD (1.00) PIK3CDPIK3R2
SCHEMBL17330914 0.80 PIK3CD (1.00) PIK3CDPIK3R2
SCHEMBL17330911 0.80 PIK3CD (1.00) PIK3CDPIK3R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3154958-A1 PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS Gilead Sciences, Inc. (US) 2017-04-19 EP claimed
WO-2015191752-A1 PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS GILEAD SCIENCES, INC. (US) 2015-12-17 WO claimed