SCHEMBL1733905

SCHEMBL1733905

COc1ccc([C@@H](CCNC(=O)Oc2csc(C)n2)N2C(=O)c3cccc(N4CCN([C@H](C)c5ccccc5)CC4)c3C2=O)cc1OC

nearest known ligand 0.74

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 19/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1733441 0.96 UTS2R (0.75) UTS2R
SCHEMBL1733630 0.90 UTS2R (0.72) UTS2R
SCHEMBL1472199 0.90 UTS2R (0.72) UTS2R
SCHEMBL1471534 0.86 UTS2R (0.74) UTS2R
SCHEMBL1734070 0.86 UTS2R (0.74) UTS2R
SCHEMBL1732792 0.86 UTS2R (0.76) UTS2R
SCHEMBL1734378 0.85 UTS2R (0.77) UTS2R
SCHEMBL1472326 0.85 UTS2R (1.00) UTS2R
SCHEMBL1472324 0.85 UTS2R (1.00) UTS2R
SCHEMBL1732748 0.85 UTS2R (0.79) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1993554-B1 UROTENSIN II RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2011-11-23 EP claimed