Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.41 |
| ▸ | KDR | P35968 | 8/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 7/20 | 0.35 |
| ▸ | AXL | P30530 | 3/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17662097 | 0.94 | BRAF (0.40) | BRAFKDRMAPK14TNNI3KMET | |
| SCHEMBL12336399 | 0.88 | BRAF (0.48) | BRAFKDRMAPK14TNNI3KFGFR2 | |
| SCHEMBL12336459 | 0.82 | BRAF (0.45) | BRAFKDRMAPK14TNNI3KAXL | |
| SCHEMBL12336466 | 0.82 | BRAF (0.47) | BRAFKDRMAPK14TNNI3KFGFR2 | |
| SCHEMBL12336222 | 0.81 | BRAF (0.51) | BRAFKDRMAPK14TNNI3KFGFR2 | |
| SCHEMBL12336406 | 0.80 | GSK3A (0.50) | BRAFKDRMAPK14TNNI3KFGFR2 | |
| SCHEMBL14949581 | 0.79 | BRAF (0.51) | BRAFKDRMAPK14TNNI3KAXL | |
| SCHEMBL14949224 | 0.79 | FGFR2 (0.41) | KDRFGFR2METAXLFLT4 | |
| SCHEMBL14949561 | 0.78 | BRAF (0.48) | BRAFKDRMAPK14TNNI3KFGFR2 | |
| SCHEMBL12336224 | 0.78 | BRAF (0.48) | BRAFKDRMAPK14TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9212151-B2 | Heterocyclic compounds useful for kinase inhibition | AMITECH THERAPEUTIC SOLUTIONS, INC. (US) | 2015-12-15 | — | — | US | disclosed |