Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 14/20 | 0.57 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | DRD3 | P35462 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17340706 | 1.00 | DRD4 (0.57) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL28806254 | 0.85 | DRD4 (0.48) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL25062785 | 0.85 | DRD4 (0.57) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL8292350 | 0.82 | DRD4 (0.55) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL23089521 | 0.82 | DRD4 (0.55) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL23089790 | 0.80 | DRD4 (0.52) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL5666313 | 0.80 | CNR2 (0.52) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL14612497 | 0.78 | SLC6A2 (0.56) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL14203043 | 0.78 | SLC6A2 (0.56) | DRD4DRD2DRD3CYP1A2CYP3A4 | |
| SCHEMBL5044079 | 0.78 | SLC6A2 (0.56) | DRD4DRD2DRD3CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678315-B1 | (Pyridin-4-yl)benzylamides as allosteric modulators of alpha 7 nAChR | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-16 | — | — | EP | disclosed |