Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 19/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 19/20 | 0.56 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1733582 | 0.90 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1 | |
| SCHEMBL1734166 | 0.89 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1 | |
| SCHEMBL1732975 | 0.86 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1 | |
| SCHEMBL1732903 | 0.77 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1 | |
| SCHEMBL1732938 | 0.76 | HSP90AA1 (0.75) | HSP90AA1HSP90AB1 | |
| SCHEMBL1733120 | 0.76 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1 | |
| SCHEMBL1732900 | 0.75 | HSP90AA1 (0.75) | HSP90AA1HSP90AB1 | |
| SCHEMBL1733637 | 0.75 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1 | |
| SCHEMBL1733249 | 0.75 | HSP90AA1 (0.72) | HSP90AA1HSP90AB1 | |
| SCHEMBL1734152 | 0.74 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035391-B1 | INDAZOLE DERIVATIVES FOR TREATING HSP90-INDUCED DISEASES | MERCK PATENT GMBH (DE) | 2011-11-23 | — | — | EP | claimed |