Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 20/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 19/20 | 0.55 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1733569 | 0.90 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1 | |
| SCHEMBL1733850 | 0.83 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1 | |
| SCHEMBL1733046 | 0.83 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1CDK8 | |
| SCHEMBL1734369 | 0.82 | HSP90AA1 (0.77) | HSP90AA1HSP90AB1 | |
| SCHEMBL1734679 | 0.82 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1 | |
| SCHEMBL1733452 | 0.80 | HSP90AA1 (0.69) | HSP90AA1HSP90AB1 | |
| SCHEMBL1733854 | 0.80 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1CDK8 | |
| SCHEMBL1732942 | 0.78 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1 | |
| SCHEMBL1733729 | 0.78 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1 | |
| SCHEMBL1733544 | 0.77 | HSP90AA1 (0.72) | HSP90AA1HSP90AB1CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035391-B1 | INDAZOLE DERIVATIVES FOR TREATING HSP90-INDUCED DISEASES | MERCK PATENT GMBH (DE) | 2011-11-23 | — | — | EP | claimed |