Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 4/20 | 0.59 |
| ▸ | CDK9 | P50750 | 4/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | EDNRA | P25101 | 9/20 | 0.48 |
| ▸ | EDNRB | P24530 | 7/20 | 0.48 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4665798 | 0.85 | BACE1 (0.58) | CYP3A4MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL15870332 | 0.84 | EDNRA (0.64) | CCNT1CDK9CYP2C9ALDH1A1MEN1 | |
| SCHEMBL17352243 | 0.84 | CCNT1 (0.65) | CCNT1CDK9MAPTALDH1A1MEN1 | |
| SCHEMBL17352250 | 0.84 | CCNT1 (0.61) | CCNT1CDK9CYP2C9CYP3A4MAPT | |
| SCHEMBL17352246 | 0.83 | EDNRA (0.65) | CCNT1CDK9CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL17352244 | 0.82 | CCNT1 (0.61) | CCNT1CDK9MAPTALDH1A1MEN1 | |
| SCHEMBL17352263 | 0.82 | CCNT1 (0.63) | CCNT1CDK9ALDH1A1MEN1KMT2A | |
| SCHEMBL17352273 | 0.82 | CCNT1 (0.61) | CCNT1CDK9CYP2C9ALDH1A1MEN1 | |
| SCHEMBL17352266 | 0.81 | CCNT1 (0.60) | CCNT1CDK9CYP2C9MAPTALDH1A1 | |
| SCHEMBL17352274 | 0.81 | CCNT1 (0.66) | CCNT1CDK9MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150368209-A1 | 4-Pyrimidinylamino-benzenesulfonamide derivatives and their use for the inhibition of polo-like kinase 1 (PLK1) for the treatment of cancer and their use for the treatment of bacterial infections | ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL) (CH) | 2015-12-24 | — | — | US | disclosed |
| US-20150368209-A1 | 4-Pyrimidinylamino-benzenesulfonamide derivatives and their use for the inhibition of polo-like kinase 1 (PLK1) for the treatment of cancer and their use for the treatment of bacterial infections | ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL) (CH) | 2015-12-24 | — | — | US | disclosed |
| US-20150368209-A1 | 4-Pyrimidinylamino-benzenesulfonamide derivatives and their use for the inhibition of polo-like kinase 1 (PLK1) for the treatment of cancer and their use for the treatment of bacterial infections | ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL) (CH) | 2015-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368209-A1 | 4-Pyrimidinylamino-benzenesulfonamide derivatives and their use for the inhibition of polo-like kinase 1 (PLK1) for the treatment of cancer and their use for the treatment of bacterial infections | PLK1, PLK2, PLK4 | CCNT1 523/4885CDK9 83/4885CYP2C9 2197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.