SCHEMBL17354293

SCHEMBL17354293

Cc1cc(F)c(NC(=O)Nc2nc(=O)c(-c3cc(F)c(CN(CCCN)CCCN)c(F)c3)c[nH]2)cc1F

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 3/20 0.32
LIMK1 P53667 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13792 0.93 CA12 (0.31)
SCHEMBL17354305 0.89 S1PR1 (0.35) ROCK2LIMK1
SCHEMBL17354160 0.89 NPSR1 (0.35)
SCHEMBL17354290 0.86 CD274 (0.34)
SCHEMBL17354128 0.86 LYN (0.32) ROCK2LIMK1
SCHEMBL17354227 0.85 LIMK1 (0.34) ROCK2LIMK1
SCHEMBL17354232 0.84 KDR (0.33) ROCK2LIMK1
SCHEMBL13794 0.83 MEN1 (0.35)
SCHEMBL17354187 0.82 HPSE (0.32) ROCK2LIMK1
SCHEMBL17354178 0.82 S1PR1 (0.32) ROCK2LIMK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9216979-B2 Antimicrobial compounds and methods of making and using the same MELINTA THERAPEUTICS, INC. (US) 2015-12-22 US disclosed