Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.37 |
| ▸ | KIT | P10721 | 3/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | FRK | P42685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17354235 | 0.92 | LIMK1 (0.34) | KDRKITFLT3ROCK2LIMK1 | |
| SCHEMBL17354350 | 0.90 | KDR (0.35) | KDRKITPDGFRAFLT3IMPDH2 | |
| SCHEMBL17354133 | 0.89 | KDR (0.41) | KDRKITPDGFRAFLT3IMPDH2 | |
| SCHEMBL17354272 | 0.88 | LIMK1 (0.39) | KDRKITPDGFRAFLT3PDGFRB | |
| SCHEMBL17486571 | 0.88 | IGF1R (0.38) | ROCK2LIMK1LYNIGF1RMEN1 | |
| SCHEMBL14850252 | 0.86 | KDR (0.39) | KDRKITFLT3LYNFGFR1 | |
| SCHEMBL14383 | 0.85 | IGF1R (0.36) | FLT3ROCK2LIMK1LYNIGF1R | |
| SCHEMBL14140 | 0.85 | IGF1R (0.34) | LYNIGF1RRAB9AKDM4EMEN1 | |
| SCHEMBL17354195 | 0.85 | PTGER3 (0.37) | KDRKITPDGFRAFLT3IMPDH2 | |
| SCHEMBL17354162 | 0.85 | KDR (0.36) | KDRKITPDGFRAFLT3IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216979-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-12-22 | — | — | US | disclosed |