Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RPA1 | P27694 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17354602 | 0.92 | S1PR1 (0.36) | MAPTTP53THRBLMNAS1PR1 | |
| SCHEMBL3105744 | 0.88 | S1PR1 (0.35) | MAPTTP53THRBS1PR1S1PR5 | |
| SCHEMBL2993582 | 0.87 | MAPT (0.56) | MAPTTP53THRBLMNAAHR | |
| SCHEMBL3087582 | 0.86 | S1PR1 (0.35) | MAPTTP53S1PR1S1PR5KDM4E | |
| SCHEMBL3234274 | 0.85 | S1PR1 (0.35) | MAPTTP53THRBLMNAS1PR1 | |
| SCHEMBL17354600 | 0.83 | MAPT (0.46) | MAPTTP53THRBLMNAPOLB | |
| SCHEMBL2990698 | 0.80 | S1PR1 (0.35) | S1PR1S1PR5KDM4ERPA1EGFR | |
| SCHEMBL2996991 | 0.79 | MAPT (0.46) | MAPTTP53THRBLMNAAHR | |
| SCHEMBL17689823 | 0.75 | KDM4E (0.33) | MAPTLMNAS1PR1S1PR5KDM4E | |
| SCHEMBL2996489 | 0.74 | RPA1 (0.34) | MAPTLMNAS1PR1S1PR5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216966-B2 | Compounds for Alzheimer's disease | Manfredi, John (US) | 2015-12-22 | — | — | US | disclosed |