Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2993831 | 0.87 | MAPT (0.55) | MAPTTP53THRBLMNAKDM4E | |
| SCHEMBL2993827 | 0.87 | MAPT (0.55) | MAPTTP53THRBLMNAKDM4E | |
| SCHEMBL2991024 | 0.87 | RPA1 (0.38) | MAPTTP53KDM4EALDH1A1POLB | |
| SCHEMBL2988858 | 0.83 | MAPT (0.41) | MAPTTP53THRBLMNAKDM4E | |
| SCHEMBL16016138 | 0.81 | MAPT (0.43) | MAPTTP53THRBLMNAKDM4E | |
| SCHEMBL2991496 | 0.81 | MAPT (0.39) | MAPTTP53THRBLMNAKDM4E | |
| SCHEMBL2988602 | 0.80 | MAPT (0.42) | MAPTTP53THRBLMNAKDM4E | |
| SCHEMBL3323176 | 0.80 | MAPT (0.64) | MAPTTP53THRBLMNAKDM4E | |
| SCHEMBL16016116 | 0.79 | KDM5A (0.36) | MAPTTP53THRBKDM4EALDH1A1 | |
| SCHEMBL17354602 | 0.79 | S1PR1 (0.36) | MAPTTP53THRBLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216966-B2 | Compounds for Alzheimer's disease | Manfredi, John (US) | 2015-12-22 | — | — | US | disclosed |