Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | CA12 | O43570 | 5/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.50 |
| ▸ | CA7 | P43166 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374105 | 0.98 | TSHR (0.57) | TSHRCA12CA14CA7CA9 | |
| SCHEMBL17188350 | 0.84 | TSHR (0.61) | TSHRCA12CA14CA7CA9 | |
| SCHEMBL1403320 | 0.83 | TSHR (0.54) | TSHRCA12CA14CA7CA9 | |
| SCHEMBL1403311 | 0.83 | TSHR (0.54) | TSHRCA12CA14CA7CA9 | |
| Dimethyl Succinate SCHEMBL27988577 | 0.82 | TSHR (0.72) | TSHRCA12CA14CA7CA9 | |
| SCHEMBL17188351 | 0.82 | TSHR (0.58) | TSHRCA12CA14CA7CA9 | |
| SCHEMBL27607572 | 0.82 | TSHR (0.44) | TSHRCA12CA14CA7CA9 | |
| SCHEMBL10119664 | 0.80 | TSHR (0.56) | TSHRCA12CA14CA7CA9 | |
| SCHEMBL13762659 | 0.80 | TSHR (0.56) | TSHRCA12CA14CA7CA9 | |
| SCHEMBL13762658 | 0.80 | TSHR (0.56) | TSHRCA12CA14CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885722-B1 | QUINOLINE DERIVATIVES AS EP4 ANTAGONISTS | MERCK CANADA INC (CA) | 2011-11-16 | — | — | EP | disclosed |
| US-20110262430-A1 | NOVEL ANTIBODIES | ELLIS JONATHAN HENRY | 2011-10-27 | — | — | US | disclosed |
| US-8013159-B2 | Quinoline derivatives as EP4 antagonists | MERCK CANADA INC. (CA) | 2011-09-06 | — | — | US | disclosed |
| US-20090099226-A1 | Quinoline derivatives as ep4 antagonists | MERCK CANADA INC. (CA) | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099226-A1 | Quinoline derivatives as ep4 antagonists | PTGER4, PTGER1, PTGER3 | TSHR 1051/4885CA12 3099/4885CA14 2032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.