Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 14/20 | 0.75 |
| ▸ | CDK1 | P06493 | 8/20 | 0.49 |
| ▸ | CDK7 | P50613 | 2/20 | 0.46 |
| ▸ | CCNH | P51946 | 2/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.46 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.45 |
| ▸ | PIP4K2B | P78356 | 3/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16123211 | 1.00 | MAPKAPK2 (0.75) | MAPKAPK2CDK1CDK7CCNHMNAT1 | |
| SCHEMBL16100755 | 0.91 | MAPKAPK2 (0.71) | MAPKAPK2CDK1CDK7CCNHMNAT1 | |
| SCHEMBL16123206 | 0.90 | MAPKAPK2 (0.75) | MAPKAPK2CDK1 | |
| SCHEMBL17361156 | 0.90 | MAPKAPK2 (0.75) | MAPKAPK2CDK1 | |
| SCHEMBL16123348 | 0.87 | MAPKAPK2 (0.56) | MAPKAPK2CDK1 | |
| SCHEMBL17361082 | 0.87 | MAPKAPK2 (0.56) | MAPKAPK2CDK1 | |
| SCHEMBL16101489 | 0.86 | MAPKAPK2 (1.00) | MAPKAPK2CDK1 | |
| SCHEMBL16123101 | 0.83 | MAPKAPK2 (0.53) | MAPKAPK2CDK1PIP4K2APIP4K2B | |
| SCHEMBL16100870 | 0.82 | MAPKAPK2 (0.70) | MAPKAPK2CDK1 | |
| SCHEMBL16123306 | 0.81 | MAPKAPK2 (0.54) | MAPKAPK2CDK1CDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190135835-A1 | MK2 INHIBITORS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2019-05-09 | — | — | US | disclosed |
| US-10138256-B2 | MK2 inhibitors and uses thereof | CELGENE CAR LLC (BM) | 2018-11-27 | — | — | US | disclosed |
| US-20150376208-A1 | MK2 INHIBITORS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2015-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376208-A1 | MK2 INHIBITORS AND USES THEREOF | MKNK2, DUSP2, MKNK1 | MAPKAPK2 7/4885CDK1 114/4885CDK7 88/4885 |
| US-10138256-B2 | MK2 inhibitors and uses thereof | MKNK2, DUSP2, MKNK1 | MAPKAPK2 7/4885CDK1 114/4885CDK7 88/4885 |
| US-20190135835-A1 | MK2 INHIBITORS AND USES THEREOF | MKNK2, DUSP2, MKNK1 | MAPKAPK2 7/4885CDK1 114/4885CDK7 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.