Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 16/20 | 0.72 |
| ▸ | CLK2 | P49760 | 14/20 | 0.72 |
| ▸ | CLK3 | P49761 | 14/20 | 0.72 |
| ▸ | WNT1 | P04628 | 7/20 | 0.59 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14792524 | 0.91 | DYRK1A (0.72) | DYRK1ACLK2CLK3WNT1CSNK2A1 | |
| SCHEMBL14804267 | 0.91 | DYRK1A (0.75) | DYRK1ACLK2CLK3WNT1 | |
| SCHEMBL14792155 | 0.91 | DYRK1A (0.70) | DYRK1ACLK2CLK3WNT1CSNK2A1 | |
| SCHEMBL20921962 | 0.89 | DYRK1A (0.73) | DYRK1ACLK2CLK3WNT1 | |
| SCHEMBL14804445 | 0.88 | DYRK1A (0.71) | DYRK1ACLK2CLK3WNT1CSNK2A1 | |
| SCHEMBL14804418 | 0.88 | DYRK1A (0.68) | DYRK1ACLK2CLK3WNT1CSNK2A1 | |
| SCHEMBL14792498 | 0.88 | DYRK1A (0.69) | DYRK1ACLK2CLK3WNT1 | |
| SCHEMBL14792485 | 0.88 | DYRK1A (0.69) | DYRK1ACLK2CLK3WNT1 | |
| SCHEMBL14792413 | 0.88 | DYRK1A (0.71) | DYRK1ACLK2CLK3WNT1 | |
| SCHEMBL14792092 | 0.88 | DYRK1A (0.69) | DYRK1ACLK2CLK3WNT1CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221793-B2 | Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors | SAMUMED, LLC (US) | 2015-12-29 | — | — | US | disclosed |