Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 6/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 6/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
| ▸ | CCND2 | P30279 | 2/20 | 0.39 |
| ▸ | CCND3 | P30281 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1735219 | 0.93 | RIPK2 (0.44) | RIPK2NOD2MCHR1MMP1MMP9 | |
| SCHEMBL1734414 | 0.82 | CDK4 (0.47) | RIPK2NOD2MCHR1ACVR1CDK4 | |
| SCHEMBL13605286 | 0.81 | MCHR1 (0.43) | RIPK2NOD2MCHR1ACVR1 | |
| SCHEMBL13605663 | 0.81 | S1PR1 (0.40) | — | |
| SCHEMBL1735220 | 0.81 | RIPK2 (0.52) | RIPK2NOD2MCHR1ACVR1ESR1 | |
| SCHEMBL1734235 | 0.81 | RIPK2 (0.43) | RIPK2NOD2MCHR1ACVR1ESR1 | |
| SCHEMBL1734449 | 0.81 | MCHR1 (0.53) | RIPK2NOD2MCHR1ACVR1KDR | |
| SCHEMBL1734406 | 0.79 | MCHR1 (0.65) | RIPK2NOD2MCHR1ACVR1ESR1 | |
| SCHEMBL13605269 | 0.79 | RIPK2 (0.46) | RIPK2NOD2MCHR1ACVR1KDR | |
| SCHEMBL13605265 | 0.79 | CDK4 (0.47) | RIPK2NOD2MCHR1ACVR1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928236-B1 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM LLC (BM) | 2011-11-23 | — | — | EP | disclosed |