Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 13/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17366165 | 0.92 | MDM2 (0.55) | MDM2TP53MEN1KMT2ACYP2C9 | |
| SCHEMBL17366163 | 0.86 | MDM2 (0.56) | MDM2TP53MEN1KMT2ACYP2C9 | |
| SCHEMBL17366178 | 0.84 | MDM2 (0.56) | MDM2TP53MEN1KMT2ACYP2C9 | |
| SCHEMBL17366182 | 0.84 | MDM2 (0.56) | MDM2TP53MEN1KMT2ACYP2C9 | |
| SCHEMBL17366148 | 0.82 | CYP2C9 (0.57) | MDM2TP53MEN1KMT2ACYP2C9 | |
| SCHEMBL17366164 | 0.80 | MDM2 (0.53) | MDM2TP53MEN1KMT2ACYP2C9 | |
| SCHEMBL12332978 | 0.78 | MDM2 (0.53) | MDM2TP53MEN1KMT2ACYP2C9 | |
| SCHEMBL17366183 | 0.78 | MDM2 (0.53) | MDM2TP53MEN1KMT2ACYP2C9 | |
| SCHEMBL17366184 | 0.76 | MDM2 (0.46) | MDM2TP53MEN1KMT2ACYP2C9 | |
| SCHEMBL17366153 | 0.74 | MDM2 (0.52) | MDM2TP53MEN1KMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2960233-A1 | NEW THERAPEUTIC AGENTS | Cancer Research Technology Limited (GB) | 2015-12-30 | — | — | EP | disclosed |