SCHEMBL17366173

SCHEMBL17366173

NOCC1(COC2(c3ccc(Cl)cc3)c3c(Cl)cccc3C(=O)N2Cc2ccc([N+](=O)[O-])cc2)CC1

nearest known ligand 0.83

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MDM2 Q00987 20/20 0.83
TP53 P04637 13/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1841111 0.91 MDM2 (1.00) MDM2TP53
SCHEMBL15864104 0.89 MDM2 (0.94) MDM2TP53
SCHEMBL7989042 0.86 MDM2 (1.00) MDM2TP53
SCHEMBL2454044 0.82 MDM2 (1.00) MDM2TP53
SCHEMBL20099593 0.79 MDM2 (0.79) MDM2TP53
SCHEMBL1821011 0.79 MDM2 (1.00) MDM2TP53
SCHEMBL21481165 0.79 MDM2 (1.00) MDM2TP53
SCHEMBL12305346 0.79 MDM2 (1.00) MDM2TP53
SCHEMBL2458741 0.78 MDM2 (1.00) MDM2TP53
SCHEMBL2457598 0.77 MDM2 (1.00) MDM2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2960233-A1 NEW THERAPEUTIC AGENTS Cancer Research Technology Limited (GB) 2015-12-30 EP disclosed