Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.59 |
| ▸ | GRK5 | P34947 | 1/20 | 0.56 |
| ▸ | BMX | P51813 | 1/20 | 0.53 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 3/20 | 0.52 |
| ▸ | ITK | Q08881 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17346653 | 0.89 | EGFR (0.54) | EGFRALKGRK5BMXBTK | |
| SCHEMBL15600773 | 0.86 | EGFR (0.55) | EGFRALKGRK5MAPK3ITK | |
| SCHEMBL14240917 | 0.86 | EGFR (0.56) | EGFRALKGRK5MAPK3 | |
| SCHEMBL17346584 | 0.84 | PTK2 (0.61) | EGFRALKBMXBTKITK | |
| SCHEMBL21541535 | 0.84 | EGFR (0.53) | EGFRALKGRK5MAPK3JAK3 | |
| SCHEMBL13726979 | 0.80 | EGFR (0.59) | EGFRALKGRK5BMXMAPK3 | |
| SCHEMBL21557773 | 0.78 | EGFR (0.62) | EGFRALKGRK5MAPK3ITK | |
| SCHEMBL14240703 | 0.78 | EGFR (0.57) | EGFRALKGRK5BMXMAPK3 | |
| SCHEMBL14240454 | 0.78 | EGFR (0.64) | EGFRALK | |
| SCHEMBL16780962 | 0.78 | EGFR (0.61) | EGFRALKGRK5MAPK3ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2704572-B1 | COMPOUNDS FOR INHIBITING CELL PROLIFERATION IN EGFR-DRIVEN CANCERS | ARIAD PHARMA INC (US) | 2015-12-30 | — | — | EP | disclosed |