SCHEMBL1737370

SCHEMBL1737370

CCCC(Nc1ccc(F)cc1)c1nccc2c(C)c(C)[nH]c12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
EGFR P00533 1/20 0.35
CDK2 P24941 6/20 0.34
CDK4 P11802 5/20 0.34
MAPT P10636 2/20 0.33
KDM4E B2RXH2 1/20 0.33
EIF2AK2 P19525 1/20 0.32
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32
CCNB2 O95067 1/20 0.32
CDK1 P06493 1/20 0.32
CCNB1 P14635 1/20 0.32
CCNA2 P20248 1/20 0.32
CCNA1 P78396 1/20 0.32
CDK5 Q00535 1/20 0.32
CDK5R1 Q15078 1/20 0.32
CCNB3 Q8WWL7 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1736131 0.99 CYP1A2 (0.37) CYP1A2CYP3A4CYP2C9CYP2C19EGFR
SCHEMBL1735327 0.91 CYP1A2 (0.39) CYP1A2CYP3A4CYP2C9CYP2C19EGFR
Hydrochloric Acid SCHEMBL1739555 0.89 CYP1A2 (0.39) CYP1A2CYP3A4CYP2C9CYP2C19EGFR
SCHEMBL1738009 0.88 CYP1A2 (0.35) CYP1A2CYP3A4CYP2C9CYP2C19EGFR
SCHEMBL1738966 0.88 CYP1A2 (0.36) CYP1A2CYP3A4CYP2C9CYP2C19EGFR
Hydrochloric Acid SCHEMBL1736325 0.87 CYP1A2 (0.34) CYP1A2CYP3A4CYP2C9CYP2C19EGFR
Hydrochloric Acid SCHEMBL1735328 0.87 CYP1A2 (0.35) CYP1A2CYP3A4CYP2C9CYP2C19EGFR
SCHEMBL1735562 0.85 CYP1A2 (0.37) CYP1A2CYP3A4CYP2C9CYP2C19EGFR
Hydrochloric Acid SCHEMBL1737734 0.84 CYP1A2 (0.37) CYP1A2CYP3A4CYP2C9CYP2C19EGFR
SCHEMBL1738025 0.83 CYP1A2 (0.36) CYP1A2CYP3A4CYP2C9CYP2C19EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1784404-B1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2011-11-16 EP claimed
US-20110263306-A1 COMPUTER SYSTEM AND PROGRAM NAMCO BANDAI GAMES INC. (JP) 2011-10-27 US claimed