Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CCNH | P51946 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17374263 | 1.00 | CCNT1 (0.32) | CCNT1CDK4CCND1CDK7CDK9 | |
| Hydrochloric Acid SCHEMBL17374457 | 0.98 | CCNT1 (0.31) | CCNT1CDK4CCND1CDK7CDK9 | |
| Hydrochloric Acid SCHEMBL17374455 | 0.98 | CCNT1 (0.31) | CCNT1CDK4CCND1CDK7CDK9 | |
| SCHEMBL17887790 | 0.74 | IDO1 (0.35) | — | |
| SCHEMBL17874200 | 0.74 | IDO1 (0.35) | — | |
| SCHEMBL19716161 | 0.74 | IDO1 (0.35) | — | |
| SCHEMBL17874224 | 0.74 | IDO1 (0.35) | — | |
| SCHEMBL17874223 | 0.74 | IDO1 (0.35) | — | |
| SCHEMBL19716157 | 0.74 | IDO1 (0.35) | — | |
| SCHEMBL17874199 | 0.74 | IDO1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3157917-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY | Proteostasis Therapeutics, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |
| WO-2015196071-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2015-12-23 | — | — | WO | disclosed |