Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17374986 | 0.91 | CRBN (0.49) | CRBNCYP3A4HTR7HTR6BRPF1 | |
| SCHEMBL17375035 | 0.90 | CRBN (0.50) | CRBNCYP3A4HTR7HTR6BRPF1 | |
| SCHEMBL17378786 | 0.88 | CRBN (0.46) | CRBNCYP3A4HTR7HTR6BRPF1 | |
| SCHEMBL17378918 | 0.88 | CRBN (0.46) | CRBNCYP3A4HTR7HTR6BRPF1 | |
| SCHEMBL1530799 | 0.82 | CRBN (0.65) | CRBNCYP3A4HTR7HTR6BRPF1 | |
| SCHEMBL17378871 | 0.76 | CRBN (0.39) | CRBNCYP3A4HTR7HTR6BRD4 | |
| SCHEMBL2454290 | 0.75 | TNIK (0.39) | CRBNCYP3A4MET | |
| SCHEMBL483387 | 0.75 | CRBN (0.67) | CRBNCYP3A4BRPF1BRD4TDP2 | |
| SCHEMBL17378872 | 0.75 | CRBN (0.37) | CRBNCYP3A4HTR7HTR6MAPK1 | |
| SCHEMBL17378895 | 0.75 | TP53 (0.37) | CRBNHPGDTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015197028-A1 | COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-12-30 | — | — | WO | disclosed |
| WO-2015197028-A1 | COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-12-30 | — | — | WO | disclosed |