Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10474017 | 0.86 | MAOB (0.60) | MAOBPKMBCHECYP4F2CYP4A11 | |
| SCHEMBL13254878 | 0.85 | MAOB (0.59) | MAOBPKMBCHECYP4F2CYP4A11 | |
| SCHEMBL15650460 | 0.84 | MAOB (0.58) | MAOBPKMBCHECYP4F2CYP4A11 | |
| SCHEMBL78171 | 0.84 | MAOB (0.62) | MAOBPKMBCHECYP4F2CYP4A11 | |
| SCHEMBL5321852 | 0.83 | TAAR1 (0.58) | MAOBTAAR1BCHENR4A2MAOA | |
| SCHEMBL10472144 | 0.81 | MAOB (0.58) | MAOBPKMBCHECYP4F2CYP4A11 | |
| SCHEMBL9434943 | 0.81 | MAOB (0.58) | MAOBPKMBCHECYP4F2CYP4A11 | |
| SCHEMBL13930902 | 0.80 | MAOB (0.57) | MAOBPKMBCHECYP4F2CYP4A11 | |
| SCHEMBL27816667 | 0.80 | MAOB (0.57) | MAOBPKMBCHECYP4F2CYP4A11 | |
| Formaldehyde SCHEMBL27492762 | 0.80 | NR4A2 (0.58) | MAOBPKMBCHECYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015197550-A1 | NOVEL DIHYDROPYRIDOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2015-12-30 | — | — | WO | disclosed |
| WO-2015197550-A1 | NOVEL DIHYDROPYRIDOISOQUINOLINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2015-12-30 | — | — | WO | disclosed |