Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 19/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL173825 | 0.93 | NAMPT (0.47) | NAMPTCYP2C9 | |
| SCHEMBL173824 | 0.92 | NAMPT (0.46) | NAMPTCYP2C9 | |
| SCHEMBL30167784 | 0.91 | NAMPT (0.61) | NAMPTCYP2C9 | |
| SCHEMBL16107769 | 0.91 | NAMPT (0.61) | NAMPTCYP2C9 | |
| SCHEMBL16108135 | 0.90 | NAMPT (0.63) | NAMPTCYP2C9HDAC1 | |
| SCHEMBL30167849 | 0.90 | NAMPT (0.63) | NAMPTCYP2C9HDAC1 | |
| SCHEMBL15531354 | 0.89 | NAMPT (0.56) | NAMPTCYP2C9 | |
| SCHEMBL16107855 | 0.86 | NAMPT (0.67) | NAMPTCYP2C9HDAC1 | |
| SCHEMBL30167791 | 0.86 | NAMPT (0.67) | NAMPTCYP2C9HDAC1 | |
| SCHEMBL15246544 | 0.84 | NAMPT (0.65) | NAMPTCYP2C9HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611804-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | claimed |
| WO-2012031197-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | claimed |