Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17382993 | 0.87 | HDAC6 (0.79) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL17383119 | 0.82 | MAPT (0.43) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL17383102 | 0.75 | POLB (0.62) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL17383072 | 0.74 | HDAC6 (0.78) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL17383067 | 0.73 | POLB (0.59) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL17383203 | 0.73 | POLB (0.59) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL17383004 | 0.71 | CYP1A2 (0.79) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL17383113 | 0.69 | POLB (0.70) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL17383364 | 0.68 | POLB (0.69) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL17383378 | 0.68 | HDAC6 (0.78) | HDAC6HDAC3HDAC1HDAC2HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981920-B2 | Inhibitors of histone deacetylase | RODIN THERAPEUTICS, INC. (US) | 2018-05-29 | — | — | US | disclosed |
| US-9981920-B2 | Inhibitors of histone deacetylase | RODIN THERAPEUTICS, INC. (US) | 2018-05-29 | — | — | US | disclosed |
| US-20170204070-A1 | INHIBITORS OF HISTONE DEACETYLASE | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2017-07-20 | — | — | US | disclosed |
| US-20170204070-A1 | INHIBITORS OF HISTONE DEACETYLASE | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2017-07-20 | — | — | US | disclosed |
| WO-2015200619-A1 | INHIBITORS OF HISTONE DEACETYLASE | RODIN THERAPEUTICS, INC. (US) | 2015-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170204070-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC2, HDAC1, HDAC5 | HDAC6 4/4885HDAC3 9/4885HDAC4 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.