Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 10/20 | 0.68 |
| ▸ | PIM3 | Q86V86 | 9/20 | 0.68 |
| ▸ | PIM1 | P11309 | 7/20 | 0.68 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL406176 | 0.90 | IRAK4 (0.56) | PIM2PIM3PIM1IRAK4 | |
| SCHEMBL400691 | 0.90 | IRAK4 (0.56) | PIM2PIM3PIM1IRAK4 | |
| SCHEMBL402152 | 0.89 | PIM2 (0.54) | PIM2PIM3PIM1IRAK4FLT3 | |
| SCHEMBL16474229 | 0.83 | PIM3 (0.61) | PIM2PIM3PIM1RETIRAK4 | |
| SCHEMBL406767 | 0.82 | CHEK1 (0.51) | PIM2PIM3PIM1FLT3CHEK1 | |
| SCHEMBL405724 | 0.81 | IRAK4 (0.49) | PIM2PIM3PIM1IRAK4FLT3 | |
| SCHEMBL405250 | 0.80 | IRAK4 (0.50) | PIM2PIM3PIM1IRAK4 | |
| SCHEMBL21996801 | 0.80 | PIM1 (0.56) | PIM2PIM3PIM1RETIRAK4 | |
| SCHEMBL406018 | 0.79 | PIM1 (0.54) | PIM2PIM3PIM1RETIRAK4 | |
| SCHEMBL405871 | 0.79 | PIM1 (0.54) | PIM2PIM3PIM1RETIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2962566-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | Genentech, Inc. (US) | 2016-01-06 | — | — | EP | disclosed |