Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 19/20 | 0.49 |
| ▸ | NTRK3 | Q16288 | 10/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 10/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15428759 | 0.83 | NTRK1 (0.68) | NTRK1NTRK3NTRK2 | |
| SCHEMBL15428650 | 0.83 | NTRK1 (0.68) | NTRK1NTRK3NTRK2 | |
| SCHEMBL15428653 | 0.83 | NTRK1 (0.68) | NTRK1NTRK3NTRK2 | |
| SCHEMBL21045866 | 0.82 | NTRK1 (0.46) | NTRK1NTRK3NTRK2TGFBR1 | |
| SCHEMBL19614296 | 0.80 | NTRK1 (0.57) | NTRK1NTRK3NTRK2 | |
| SCHEMBL16936006 | 0.80 | NTRK1 (0.57) | NTRK1NTRK3NTRK2 | |
| SCHEMBL29497207 | 0.79 | NTRK1 (0.52) | NTRK1NTRK3NTRK2 | |
| SCHEMBL15428677 | 0.79 | NTRK1 (0.58) | NTRK1NTRK3NTRK2 | |
| SCHEMBL15428585 | 0.79 | NTRK1 (0.58) | NTRK1NTRK3NTRK2 | |
| SCHEMBL15428641 | 0.79 | NTRK1 (0.58) | NTRK1NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2962566-A1 | PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS | Genentech, Inc. (US) | 2016-01-06 | — | — | EP | disclosed |