Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15021780 | 0.91 | MAPK1 (0.51) | MAPK1MAPK3MAP2K2MAP2K1MAPK6 | |
| SCHEMBL15021916 | 0.85 | MAPK1 (0.53) | MAPK1MAPK3MAP2K2MAP2K1MAPK6 | |
| SCHEMBL176052 | 0.84 | MAPK1 (0.57) | MAPK1MAPK3MAP2K2MAP2K1MAPK6 | |
| SCHEMBL173759 | 0.83 | MAPK1 (0.56) | MAPK1MAPK3MAP2K2MAP2K1MAPK6 | |
| SCHEMBL15021550 | 0.82 | MAPK1 (0.52) | MAPK1MAPK3MAP2K2MAP2K1MAPK6 | |
| SCHEMBL173256 | 0.82 | MAPK1 (0.53) | MAPK1MAPK3MAP2K2MAP2K1MAPK6 | |
| SCHEMBL15021943 | 0.81 | MAPK1 (0.53) | MAPK1MAPK3MAP2K2MAP2K1MAPK6 | |
| SCHEMBL15021911 | 0.81 | MAPK1 (0.51) | MAPK1MAPK3MAP2K2MAP2K1MAPK6 | |
| SCHEMBL15021560 | 0.81 | MAPK1 (0.51) | MAPK1MAPK3MAP2K2MAP2K1MAPK6 | |
| SCHEMBL176241 | 0.81 | MAPK1 (0.54) | MAPK1MAPK3MAP2K2MAP2K1MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613782-A2 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012030685-A2 | INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |