Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aleglitazar. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 20/20 | 0.89 |
| ▸ | PPARA known ✓ | Q07869 | 20/20 | 0.89 |
| ▸ | PPARD | Q03181 | 6/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aleglitazar SCHEMBL19457970 | 1.00 | PPARG (0.89) | PPARGPPARAPPARD | |
| Aleglitazar SCHEMBL482285 | 0.94 | PPARG (1.00) | PPARGPPARAPPARD | |
| Aleglitazar SCHEMBL483251 | 0.94 | PPARG (1.00) | PPARGPPARAPPARD | |
| Aleglitazar SCHEMBL30193480 | 0.94 | PPARG (1.00) | PPARGPPARAPPARD | |
| Aleglitazar SCHEMBL482284 | 0.94 | PPARG (1.00) | PPARGPPARAPPARD | |
| SCHEMBL5762070 | 0.91 | PPARG (0.88) | PPARGPPARAPPARD | |
| SCHEMBL5760889 | 0.88 | PPARG (0.85) | PPARGPPARAPPARD | |
| SCHEMBL5759052 | 0.88 | PPARG (1.00) | PPARGPPARAPPARD | |
| SCHEMBL5762025 | 0.88 | PPARG (0.85) | PPARGPPARAPPARD | |
| SCHEMBL5763710 | 0.88 | PPARG (1.00) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2895469-B1 | SOLID FORMS OF (S)-2-METHOXY-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-BENZO[B]THIOPHEN-7-YL}-PROPIONIC ACID AND OF SALTS THEREOF | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | claimed |
| EP-2389166-A1 | PHARMACEUTICAL COMPOSITION COMPRISING ALEGLITAZAR | F. Hoffmann-La Roche AG (CH) | 2011-11-30 | — | — | EP | disclosed |
| US-D647146-S1 | Doll with audio playback | ISLAVA STEVE | 2011-10-18 | — | — | US | disclosed |