Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 6/20 | 0.70 |
| ▸ | PLK1 | P53350 | 5/20 | 0.70 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | GAK | O14976 | 1/20 | 0.61 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.61 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.61 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.57 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.57 |
| ▸ | EGFR | P00533 | 7/20 | 0.57 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
| ▸ | CCND1 | P24385 | 1/20 | 0.52 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17396371 | 0.93 | TTK (0.61) | TTKPLK1PLK4GAKSTK33 | |
| SCHEMBL17396494 | 0.92 | TTK (0.59) | TTKPLK1PLK4GAKSTK33 | |
| SCHEMBL17396401 | 0.91 | TTK (0.59) | TTKPLK1DCLK1MAPK7LRRK2 | |
| SCHEMBL17396589 | 0.90 | TTK (0.65) | TTKPLK1PLK4GAKSTK33 | |
| SCHEMBL17396381 | 0.90 | TTK (0.57) | TTKPLK1PLK4GAKSTK33 | |
| SCHEMBL17396396 | 0.90 | PLK1 (0.57) | TTKPLK1PLK4GAKSTK33 | |
| SCHEMBL17396415 | 0.89 | TTK (0.56) | TTKPLK1DCLK1MAPK7LRRK2 | |
| SCHEMBL17396509 | 0.88 | TTK (0.55) | TTKPLK1PLK4GAKSTK33 | |
| SCHEMBL17396462 | 0.87 | TTK (0.65) | TTKPLK1PLK4GAKSTK33 | |
| SCHEMBL17396590 | 0.86 | EGFR (0.57) | TTKPLK1DCLK1MAPK7LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001077-A1 | COMPOUNDS INHIBITING THE ENZYME MONOPOLAR SPINDLE 1 KINASE,PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2016-01-07 | — | — | WO | claimed |
| WO-2016001077-A1 | COMPOUNDS INHIBITING THE ENZYME MONOPOLAR SPINDLE 1 KINASE,PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2016-01-07 | — | — | WO | disclosed |