Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.63 |
| ▸ | JAK3 | P52333 | 20/20 | 0.63 |
| ▸ | JAK2 | O60674 | 12/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | TYK2 | P29597 | 1/20 | 0.61 |
| ▸ | SYK | P43405 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1739700 | 0.94 | JAK1 (0.62) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL1742694 | 0.93 | JAK1 (0.63) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL1740912 | 0.90 | JAK1 (0.62) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL1740653 | 0.87 | JAK1 (0.63) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL1741112 | 0.86 | JAK1 (0.66) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL341253 | 0.85 | JAK1 (0.71) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL339446 | 0.83 | JAK1 (0.66) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL340866 | 0.83 | JAK1 (0.86) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL342148 | 0.82 | JAK3 (0.69) | JAK1JAK3JAK2CYP3A4CYP1A2 | |
| SCHEMBL341375 | 0.82 | JAK1 (0.82) | JAK1JAK3JAK2CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389372-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2011-11-30 | — | — | EP | disclosed |
| US-8037782-B2 | Steering column assembly | FUJI KIKO CO., LTD. (JP) | 2011-10-18 | — | — | US | disclosed |
| WO-2010085684-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2010-07-29 | — | — | WO | disclosed |