Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397201 | 0.93 | PIK3CD (0.58) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3R1 | |
| SCHEMBL17397121 | 0.87 | PIK3CD (0.66) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3R1 | |
| SCHEMBL17397312 | 0.84 | PIK3CD (0.53) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3R1 | |
| SCHEMBL17397151 | 0.83 | PIK3CD (0.54) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3R1 | |
| SCHEMBL17397210 | 0.83 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3R1 | |
| SCHEMBL17397157 | 0.82 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3R1 | |
| SCHEMBL17397228 | 0.82 | PIK3CD (0.55) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3R1 | |
| SCHEMBL17397132 | 0.81 | PIK3CD (0.52) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3R1 | |
| SCHEMBL17401195 | 0.81 | PIK3CD (1.00) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3R1 | |
| SCHEMBL17397177 | 0.81 | PIK3CD (1.00) | PIK3CDPIK3CBPIK3CGPIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | disclosed |