Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.77 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17401189 | 1.00 | PIK3CD (0.77) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL17401176 | 1.00 | PIK3CD (0.77) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL17401090 | 0.91 | PIK3CD (0.65) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL17401050 | 0.91 | PIK3CD (0.65) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL17397196 | 0.91 | PIK3CD (0.65) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL17401182 | 0.88 | PIK3CD (0.63) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL17713865 | 0.88 | PIK3CD (0.60) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL17397277 | 0.88 | PIK3CD (0.63) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL17401149 | 0.88 | PIK3CD (0.63) | PIK3CDPIK3CBPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL17401060 | 0.87 | PIK3CD (0.77) | PIK3CDPIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944639-B2 | Quinolizinone derivatives as PI3K inhibitors | LUPIN LIMITED (IN) | 2018-04-17 | — | — | US | claimed |
| US-20180036293-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2018-02-08 | — | — | US | claimed |
| EP-3224248-A1 | CERTAIN PROTEIN KINASE INHIBITORS | Shanghai Fochon Pharmaceutical Co. Ltd (CN) | 2017-10-04 | — | — | EP | claimed |
| US-20170137421-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2017-05-18 | — | — | US | claimed |
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | claimed |
| WO-2016066142-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2016-05-06 | — | — | WO | claimed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | claimed |
| EP-3224248-B1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO LTD (CN) | 2021-05-05 | — | — | EP | disclosed |
| EP-3224248-B1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO LTD (CN) | 2021-05-05 | — | — | EP | disclosed |
| CN-107207441-B | Protein kinase inhibitors | 上海复尚慧创医药研究有限公司 | 2020-11-24 | — | — | CN | disclosed |
| US-10328060-B2 | Certain protein kinase inhibitors | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2019-06-25 | — | — | US | disclosed |
| US-10328060-B2 | Certain protein kinase inhibitors | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2019-06-25 | — | — | US | disclosed |
| US-9944639-B2 | Quinolizinone derivatives as PI3K inhibitors | LUPIN LIMITED (IN) | 2018-04-17 | — | — | US | disclosed |
| US-20180036293-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2018-02-08 | — | — | US | disclosed |
| EP-3224248-A1 | CERTAIN PROTEIN KINASE INHIBITORS | Shanghai Fochon Pharmaceutical Co. Ltd (CN) | 2017-10-04 | — | — | EP | disclosed |
| US-20170137421-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2017-05-18 | — | — | US | disclosed |
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016066142-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2016-05-06 | — | — | WO | disclosed |
| WO-2016066142-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2016-05-06 | — | — | WO | disclosed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180036293-A1 | CERTAIN PROTEIN KINASE INHIBITORS | AKT1, PIK3CA, AKT3 | PIK3CD 6/4885PIK3CB 5/4885PIK3CA 2/4885 |
| US-10328060-B2 | Certain protein kinase inhibitors | AKT1, PIK3CA, AKT3 | PIK3CD 6/4885PIK3CB 5/4885PIK3CA 2/4885 |
| US-20170137421-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | PIK3R5, PIK3R1, PIK3R4 | PIK3CD 5/4885PIK3CB 14/4885PIK3CA 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.