Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397197 | 0.91 | PIK3CD (0.44) | PIK3CDPIK3CBAURKABTK | |
| SCHEMBL17397290 | 0.87 | PIK3CD (0.53) | PIK3CDPIK3CBMAPK1HTTTAAR1 | |
| SCHEMBL17397279 | 0.87 | PIK3CD (0.44) | PIK3CDPIK3CBMAPK1HTTTAAR1 | |
| SCHEMBL17397103 | 0.84 | PIK3CD (0.53) | PIK3CDPIK3CBMAPK1HTTTAAR1 | |
| SCHEMBL17397286 | 0.82 | PIK3CD (0.50) | PIK3CDPIK3CBPIK3CALMNAAURKA | |
| SCHEMBL17397231 | 0.81 | PIK3CD (0.47) | PIK3CDPIK3CBPIK3CALMNA | |
| SCHEMBL17397157 | 0.81 | PIK3CD (0.47) | PIK3CDPIK3CBMAPK1HTTTAAR1 | |
| SCHEMBL17397132 | 0.80 | PIK3CD (0.52) | PIK3CDPIK3CBPIK3CA | |
| SCHEMBL17397252 | 0.79 | PIK3CD (0.44) | PIK3CDPIK3CBPIK3CA | |
| SCHEMBL17331766 | 0.78 | PIK3CD (0.39) | PIK3CDMAPK1HTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | claimed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | claimed |
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | disclosed |