Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 16/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397071 | 0.95 | PIK3CD (0.46) | PIK3CAPIK3CDPIK3CBPIK3CGNUDT1 | |
| SCHEMBL17397169 | 0.94 | PIK3CD (0.44) | PIK3CAPIK3CDPIK3CBPIK3CGNUDT1 | |
| SCHEMBL17397134 | 0.92 | PIK3CD (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGNUDT1 | |
| SCHEMBL17397231 | 0.89 | PIK3CD (0.47) | PIK3CAPIK3CDPIK3CBBRD4 | |
| SCHEMBL17397215 | 0.87 | PIK3CD (0.40) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL17397192 | 0.86 | PIK3CD (0.37) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL17397290 | 0.83 | PIK3CD (0.53) | PIK3CAPIK3CDPIK3CB | |
| SCHEMBL17397252 | 0.82 | PIK3CD (0.44) | PIK3CAPIK3CDPIK3CB | |
| SCHEMBL17397259 | 0.80 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL17401187 | 0.79 | PIK3CA (0.67) | PIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | claimed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | claimed |
| EP-3164400-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | Lupin Limited (IN) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016001855-A1 | QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS | LUPIN LIMITED (IN) | 2016-01-07 | — | — | WO | disclosed |